Ruscheweyh, Hans-Joachim


Publications
2

Biosynthetic potential of the global ocean microbiome

Citation
Paoli et al. (2022). Nature 607 (7917)
Names
“Eudoremicrobium” “Eudoremicrobiaceae” “Eudoremicrobium malaspinii”
Abstract
AbstractNatural microbial communities are phylogenetically and metabolically diverse. In addition to underexplored organismal groups1, this diversity encompasses a rich discovery potential for ecologically and biotechnologically relevant enzymes and biochemical compounds2,3. However, studying this diversity to identify genomic pathways for the synthesis of such compounds4 and assigning them to their respective hosts remains challenging. The biosynthetic potential of microorganisms in the open oc

Uncharted biosynthetic potential of the ocean microbiome

Citation
Paoli et al. (2021).
Names
“Eudoremicrobiaceae” “Eudoremicrobium malaspinii”
Abstract
SummaryMicrobes are phylogenetically and metabolically diverse. Yet capturing this diversity, assigning functions to host organisms and exploring the biosynthetic potential in natural environments remains challenging. We reconstructed >25,000 draft genomes, including from >2,500 uncharacterized species, from globally-distributed ocean microbial communities, and combined them with ∼10,000 genomes from cultivated and single cells. Mining this resource revealed ∼40,000 putative biosynthetic g