He, Xuesong

Publications (4)

Draft Genome Sequences of Nine “ Candidatus Nanosynbacter sp. HMT-352” Strains Cultured from the Human Oral Cavity

Liu et al. (2022). Microbiology Resource Announcements 11 (8)
Names (2)
Ca. Saccharibacteria Ca. Nanosynbacter
Genetics Immunology and Microbiology (miscellaneous) Molecular Biology
Here, we report draft genome sequences for nine strains of “ Candidatus Nanosynbacter sp. HMT-352.” These strains and their sequences were used to interrogate strain-level variations in host range, gene content, and growth dynamics among the phylum “ Candidatus Saccharibacteria.”

Cultivation of a human-associated TM7 phylotype reveals a reduced genome and epibiotic parasitic lifestyle

He et al. (2015). Proceedings of the National Academy of Sciences 112 (1)
Names (1)
Ca. Nanosynbacter
Significance TM7 is one of the most enigmatic bacterial phyla among the uncultivated candidate phyla referred to as “microbial dark matter,” and it has potential pathogenic associations. We revealed molecular insights into its uncultivability and pathogenicity, as well its unique epibiotic and parasitic lifestyle phases. These novel discoveries shed significant light on the biological, ecological, and medical importance of TM7, as well as providing useful information for culturing other TM7 and currently uncultivable bacteria that may evade standard cultivation approaches.